History of innovation



Combination vaccines, those that protect against multiple diseases, are one of the strengths of Sanofi Pasteur's product range. They offer the advantage of simplifying vaccination schedules, decreasing the number of injections and the health-related costs.
Since the beginning of the 20th century, many innovative discoveries have been made in vaccines.

Milestones: Dates of first license for Sanofi Pasteur's* major products

* or from the companies which have preceded it in its current legal status.

After 1966, dates correspond to when marketing authorization was first obtained.

1907 [1] Sera production
1922 [2] First tetanus vaccine
1939 New application of the percutaneous reaction
1939 First use of the Mérieux tuberculin
1946 Anti-pertussis serum
1953 Yellow fever vaccine
1955 [3] First Salk (inactivated) polio vaccine (injectable)
1960 Lépine (inactivated) polio vaccine (injectable)
1962 First Sabin (attenuated) polio vaccine (oral)
1963 Tuberculin multipuncture ring
1968 Measles vaccine
1968 Influenza vaccine
1970 Rubella vaccine (human diploid origin)
1974 First group A Meningococcal vaccine
1975 First groups A+C Meningococcal vaccine
1975 Vaccine against diphtheria, tetanus, pertussis and polio (injectable)
1977 First rabies vaccine (human diploid origin)
1981 First plasmatic hepatitis B vaccine
1982 First injectable Salk polio vaccine (on Vero cells)
1985 [4] First rabies vaccine (on Vero cells)
1986 MMR (Measles-Mumps-Rubella) vaccine
1987 Hepatitis B vaccine (based on genetic engineering)
1987 First Haemophilus influenzae type b conjugate vaccine
1988 First oral Sabin polio vaccine (Vero cells)
1988 First typhoid vaccine (polysaccharides)
1992 [5] DT acellular pertussis vaccine for adults
1993 Vaccine against diphtheria, tetanus, pertussis (whole cell) and Haemophilus influenzae type b
1993 First pentavalent diphtheria, tetanus, pertussis (whole cell), poliomyelitis and Haemophilus influenzae type b vaccine (awarded the Galien Prize in 1994) 
1996 [6] Hepatitis A vaccine
1997 First pentavalent vaccine with acellular pertussis 
1998 Diphtheria, tetanus, pertussis (acellular) and poliomyelitis vaccine
1999 Adult booster against tetanus, diphtheria, and polio
2004 [7] First quadrivalent conjugate vaccine against meningococcal disease
2005 Conjugate vaccine against meningococcal meningitis (A+C+W+Y)
Monovalent oral polio vaccine (type 1) 
2007 H5N1 pandemic influenza vaccine (to anticipate a potential pandemic)
2008 Smallpox vaccine (to anticipate a potential bioterrorism attack)
First micro-needle vaccine against influenza
2009 A(H1N1) monovalent influenza vaccine
2015 First dengue vaccine

[1] Institut Biologique Mérieux
[2] Institut Mérieux
[3] By Connaught Laboratories, bought by Institut Mérieux in 1989
[4] Merger of Institut Mérieux & Institut Pasteur Production created in 1973.
Pasteur Vaccins is founded
[5] By Pasteur Mérieux Sérums & Vaccins, created in 1990.
[6] Pasteur Mérieux Connaught
[7] By Aventis Pasteur, new name of Pasteur Mérieux Connaught after the merger of Rhône-Poulenc and Hoechst Life Sciences activities in 1999, to form a single company, Aventis.


We produce a portfolio of high quality vaccines that matches our areas of expertise and ensures a sustainable future